@2 hours ago with 2088 note and 37359 play

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@1 day ago with 118216 notes
@2 days ago with 12776 notes

dulect:

wow they really did adapt frozen well

(via callmekev)

@3 days ago with 74277 notes

Anonymous asked: I'm glad it's better! Is Sigma Chi a social fraternity that just parties?

Me too! It is a social fraternity/brotherhood that emphasizes on developing quality young men/gentlemen. I think Sigma Chi prides itself in housing noble young men/being the sweethearts. There are parties, there are the typical greek philanthropies, but I think what’s so different is it’s focus on self-discovery and development. As you can tell, I really respect and love the fraternity.

@4 days ago

weloveshortvideos:

Do it for the vine - Vine by Mahlissa Jayde

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@6 days ago with 2042 notes

"hella cute questions"

1. Who was the last person you held hands with?
2. Are you outgoing or shy?
3. Who are you looking forward to seeing?
4. Are you easy to get along with?
5. If you were drunk would the person you like take care of you?
6. What kind of people are you attracted to?
7. Do you think you’ll be in a relationship two months from now?
8. Who from the opposite gender is on your mind?
9. Does talking about sex make you uncomfortable?
10. Who was the last person you had a deep conversation with?
11. What does the most recent text that you sent say?
12. What are your 5 favorite songs right now?
13. Do you like it when people play with your hair?
14. Do you believe in luck and miracles?
15. What good thing happened this summer?
16. Would you kiss the last person you kissed again?
17. Do you think there is life on other planets?
18. Do you still talk to your first crush?
19. Do you like bubble baths?
20. Do you like your neighbors?
21. What are you bad habits?
22. Where would you like to travel?
23. Do you have trust issues?
24. Favorite part of your daily routine?
25. What part of your body are you most uncomfortable with?
26. What do you do when you wake up?
27. Do you wish your skin was lighter or darker?
28. Who are you most comfortable around?
29. Have any of your ex’s told you they regret breaking up?
30. Do you ever want to get married?
31. If your hair long enough for a pony tail?
32. Which celebrities would you have a threesome with?
33. Spell your name with your chin.
34. Do you play sports? What sports?
35. Would you rather live without TV or music?
36. Have you ever liked someone and never told them?
37. What do you say during awkward silences?
38. Describe your dream girl/guy?
39. What are your favorite stores to shop in?
40. What do you want to do after high school?
41. Do you believe everyone deserves a second chance?
42. If your being extremely quiet what does it mean?
43. Do you smile at strangers?
44. Trip to outer space or bottom of the ocean?
45. What makes you get out of bed in the morning?
46. What are you paranoid about?
47. Have you ever been high?
48. Have you ever been drunk?
49. Have you done anything recently that you hope nobody finds out about?
50. What was the colour of the last hoodie you wore?
51. Ever wished you were someone else?
52. One thing you wish you could change about yourself?
53. Favourite makeup brand?
54. Favourite store?
55. Favourite blog?
56. Favourite colour?
57. Favourite food?
58. Last thing you ate?
59. First thing you ate this morning?
60. Ever won a competition? For what?
61. Been suspended/expelled? For what?
62. Been arrested? For what?
63. Ever been in love?
64. Tell us the story of your first kiss?
65. Are you hungry right now?
66. Do you like your tumblr friends more than your real friends?
67. Facebook or Twitter?
68. Twitter or Tumblr?
69. Are you watching tv right now?
70. Names of your bestfriends?
71. Craving something? What?
72. What colour are your towels?
72. How many pillows do you sleep with?
73. Do you sleep with stuffed animals?
74. How many stuffed animals do you think you have?
75. Favourite animal?
76. What colour is your underwear?
77. Chocolate or Vanilla?
78. Favourite ice cream flavour?
79. What colour shirt are you wearing?
80. What colour pants?
81. Favourite tv show?
82. Favourite movie?
83. Mean Girls or Mean Girls 2?
84. Mean Girls or 21 Jump Street?
85. Favourite character from Mean Girls?
86. Favourite character from Finding Nemo?
87. First person you talked to today?
88. Last person you talked to today?
89. Name a person you hate?
90. Name a person you love?
91. Is there anyone you want to punch in the face right now?
92. In a fight with someone?
93. How many sweatpants do you have?
94. How many sweaters/hoodies do you have?
95. Last movie you watched?
96. Favourite actress?
97. Favourite actor?
98. Do you tan a lot?
99. Have any pets?
100. How are you feeling?
101. Do you type fast?
102. Do you regret anything from your past?
103. Can you spell well?
104. Do you miss anyone from your past?
105. Ever been to a bonfire party?
106. Ever broken someone’s heart?
107. Have you ever been on a horse?
108. What should you be doing?
109. Is something irritating you right now?
110. Have you ever liked someone so much it hurt?
111. Do you have trust issues?
112. Who was the last person you cried in front of?
113. What was your childhood nickname?
114. Have you ever been out of your province/state?
115. Do you play the Wii?
116. Are you listening to music right now?
117. Do you like chicken noodle soup?
118. Do you like Chinese food?
119. Favourite book?
120. Are you afraid of the dark?
121. Are you mean?
122. Is cheating ever okay?
123. Can you keep white shoes clean?
124. Do you believe in love at first sight?
125. Do you believe in true love?
126. Are you currently bored?
127. What makes you happy?
128. Would you change your name?
129. What your zodiac sign?
130. Do you like subway?
131. Your bestfriend of the opposite sex likes you, what do you do?
132. Who’s the last person you had a deep conversation with?
133. Favourite lyrics right now?
134. Can you count to one million?
135. Dumbest lie you ever told?
136. Do you sleep with your doors open or closed?
137. How tall are you?
138. Curly or Straight hair?
139. Brunette or Blonde?
140. Summer or Winter?
141. Night or Day?
142. Favourite month?
143. Are you a vegetarian?
144. Dark, milk or white chocolate?
145. Tea or Coffee?
146. Was today a good day?
147. Mars or Snickers?
148. What’s your favourite quote?
149. Do you believe in ghosts?
150. Get the closest book next to you, open it to page 42, what’s the first line on that page? (via cubansandwitch)

PLEASE

(via youhelpedbuildthisfireinsideofme)

Omg please i’ll answer all of em <3

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(Source: catscuddlingandyou, via dafunnybee)

@1 day ago with 846444 notes

(Source: st4ysane, via dafunnybee)

@1 day ago with 21873 notes

joeycab:

feelin myself | WILL.I.AM

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@3 days ago with 28 note and 480 play
neurosciencestuff:

New mouse model could revolutionize research in Alzheimer’s disease
In a study published today in Nature Neuroscience, a group of researchers led by Takaomi Saido of the RIKEN Brain Science Institute in Japan have reported the creation of two new mouse models of Alzheimer’s disease that may potentially revolutionize research into this disease. 

Alzheimer’s disease, the primary cause of dementia in the elderly, imposes a tremendous social and economic burden on modern society. In Japan, the burden of the disease in 2050 is estimated to be a half a trillion US dollars, a figure equivalent to the government’s annual revenues.
Unfortunately, it has proven very difficult to develop drugs capable of ameliorating the disease. After a tremendous burst of progress in the 1990s, the pace of discoveries has slowed. Dr. Saido believes that part of the difficulty is the inadequacy of current mouse models to replicate the real conditions of Alzheimer’s disease and allow an understanding of the underlying mechanisms that lead to neurodegeneration. In fact, much of the research in Alzheimer’s disease over the past decade may be flawed, as it was based on unrealistic models.
The problem with older mouse models is that they overexpress a protein called amyloid precursor protein, or APP, which gives rise to the amyloid-beta (Abeta) peptides that accumulate in the brain, eventually leading to the neurodegeneration that characterizes Alzheimer’s disease. However, in mice the overexpression of APP gives rise to effects which are not seen in human Alzheimer’s disease.
For example, the APP mutant mice often die of unknown causes at a young age, and the group believes this may be related to the generation of toxic fragments of APP, such as CTF-beta. In addition, some of the fragments of APP could be neuroprotective, making it difficult to judge whether drugs are being effective due to their effect on Abeta peptides, which are known to be involved in human AD, or whether it is due to other effects that would not be seen in human disease. In addition, the gene for expressing APP is inserted in different places in the genome, and may knock out other genes, creating artifacts that are not seen in humans.
With this awareness, more than a decade ago Dr. Saido launched a project to develop a new mouse model that would allow more accurate evaluation of therapies for the disease. One of the major hurdles involved a part of the gene, intron 16, which they discovered was necessary for creating more specific models.
The first mice model they developed (NL-F/NL-F) was knocked in with two mutations found in human familial Alzheimer’s disease. The mice showed early accumulation of Abeta peptides, and importantly, were found to undergo cognitive dysfunction similar to the progression of AD seen in human patients. A second model, with the addition of a further mutation that had been discovered in a family in Sweden, showed even faster initiation of memory loss.
These new models could help in two major areas. The first model, which expresses high levels of the Abeta peptides, seems to realistically model the human form of AD, and could be used for elucidating the mechanism of Abeta deposition. The second model, which demonstrates AD pathology very early on, could be used to examine factors downstream of Abeta-40 and Abeta-42 deposition, such as tauopathy, which are believed to be involved in the neurodegeneration. These results may eventually contribute to drug development and to the discovery of new biomarkers for Alzheimer’s disease. The group is currently looking at several proteins, using the new models, which have potential to be biomarkers.
According to Dr. Saido, “We have a social responsibility to make Alzheimer’s disease preventable and curable. The generation of appropriate mouse models will be a major breakthrough for understanding the mechanism of the disease, which will lead to the establishment of presymptomatic diagnosis, prevention and treatment of the disease.”

neurosciencestuff:

New mouse model could revolutionize research in Alzheimer’s disease

In a study published today in Nature Neuroscience, a group of researchers led by Takaomi Saido of the RIKEN Brain Science Institute in Japan have reported the creation of two new mouse models of Alzheimer’s disease that may potentially revolutionize research into this disease.

Alzheimer’s disease, the primary cause of dementia in the elderly, imposes a tremendous social and economic burden on modern society. In Japan, the burden of the disease in 2050 is estimated to be a half a trillion US dollars, a figure equivalent to the government’s annual revenues.

Unfortunately, it has proven very difficult to develop drugs capable of ameliorating the disease. After a tremendous burst of progress in the 1990s, the pace of discoveries has slowed. Dr. Saido believes that part of the difficulty is the inadequacy of current mouse models to replicate the real conditions of Alzheimer’s disease and allow an understanding of the underlying mechanisms that lead to neurodegeneration. In fact, much of the research in Alzheimer’s disease over the past decade may be flawed, as it was based on unrealistic models.

The problem with older mouse models is that they overexpress a protein called amyloid precursor protein, or APP, which gives rise to the amyloid-beta (Abeta) peptides that accumulate in the brain, eventually leading to the neurodegeneration that characterizes Alzheimer’s disease. However, in mice the overexpression of APP gives rise to effects which are not seen in human Alzheimer’s disease.

For example, the APP mutant mice often die of unknown causes at a young age, and the group believes this may be related to the generation of toxic fragments of APP, such as CTF-beta. In addition, some of the fragments of APP could be neuroprotective, making it difficult to judge whether drugs are being effective due to their effect on Abeta peptides, which are known to be involved in human AD, or whether it is due to other effects that would not be seen in human disease. In addition, the gene for expressing APP is inserted in different places in the genome, and may knock out other genes, creating artifacts that are not seen in humans.

With this awareness, more than a decade ago Dr. Saido launched a project to develop a new mouse model that would allow more accurate evaluation of therapies for the disease. One of the major hurdles involved a part of the gene, intron 16, which they discovered was necessary for creating more specific models.

The first mice model they developed (NL-F/NL-F) was knocked in with two mutations found in human familial Alzheimer’s disease. The mice showed early accumulation of Abeta peptides, and importantly, were found to undergo cognitive dysfunction similar to the progression of AD seen in human patients. A second model, with the addition of a further mutation that had been discovered in a family in Sweden, showed even faster initiation of memory loss.

These new models could help in two major areas. The first model, which expresses high levels of the Abeta peptides, seems to realistically model the human form of AD, and could be used for elucidating the mechanism of Abeta deposition. The second model, which demonstrates AD pathology very early on, could be used to examine factors downstream of Abeta-40 and Abeta-42 deposition, such as tauopathy, which are believed to be involved in the neurodegeneration. These results may eventually contribute to drug development and to the discovery of new biomarkers for Alzheimer’s disease. The group is currently looking at several proteins, using the new models, which have potential to be biomarkers.

According to Dr. Saido, “We have a social responsibility to make Alzheimer’s disease preventable and curable. The generation of appropriate mouse models will be a major breakthrough for understanding the mechanism of the disease, which will lead to the establishment of presymptomatic diagnosis, prevention and treatment of the disease.”

@4 days ago with 139 notes

Anonymous asked: How is UCI now?

It is better. Still about the people, not so much the classes lol. Trying to double major into Neurobio and minor in Mat Sci now! Found an assortment of classes I actually find interesting/care for, so looking a little more forward into the future. Going to be put back onto my research project with the Tang lab next year, and might intern at Fischer&Price this summer so woot. lol I-week this week for Sigma Chi! Going to be initiated soon! yeeyee #inhoc

@5 days ago

Anonymous asked: I'm really glad we're friends :)

I would be too if I knew who you were!

@6 days ago